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HelpTest ID: CEASF Carcinoembryonic Antigen (CEA), Spinal Fluid
Reporting Name
Carcinoembryonic Ag (CEA), CSFUseful For
Detecting meningeal carcinomatosis and intradural or extradural infiltration
Differentiating brain parenchymal metastasis from adenocarcinoma or squamous-cell carcinoma
Specimen Type
CSFSpecimen Required
Collection Container/Tube: Sterile vial
Submission Container/Tube: 13 x 75-mm tube
Specimen Volume: 0.5 mL
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days | ||
| Ambient | 7 days |
Reference Values
<0.6 ng/mL
Tumor markers are not specific for malignancy, and values may vary by method.
Day(s) Performed
Monday through Saturday
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82378
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CEASF | Carcinoembryonic Ag (CEA), CSF | 2037-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| CEASF | Carcinoembryonic Ag (CEA), CSF | 2037-0 |
Clinical Information
Carcinoembryonic antigen (CEA) normally is present in cerebrospinal fluid (CSF) in very low concentrations. Elevations in serum CEA can cause passive transfer to CSF. Tumors of the brain, especially metastatic tumors, can elevate CSF CEA.
Interpretation
Increased values are seen in approximately 60% of patients with meningeal carcinomatosis.
Clinical Reference
1. Klee GG, Tallman RD, Goellner JR, Yanagihara T: Elevation of carcinoembryonic antigen in cerebrospinal fluid among patients with meningeal carcinomatosis. Mayo Clin Proc. 1986 Jan;61(1):9-13
2. Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Tangen C: An evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer. JAMA. 1993 Aug 25;270(8):943-947
3. Duffy MJ: Carcinogenic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem. 2001 Apr;47(4):624-630
4. Block DR, Algeciras-Schimnich A: Body fluid analysis: clinical utility and applicability of published studies to guide interpretation of today's laboratory testing in serous fluids. Crit Rev Clin Lab Sci. 2013 Jul-Oct;5(4-5):107-124
Report Available
1 to 3 daysMethod Name
Immunoenzymatic Assay
Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.
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